BBQ Compound May Cure Diabetes

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mouse-lab-rat-101117-02Thanks to recent discoveries at Oregon State University, mice diagnosed with type 1 diabetes can rest assured there is hope. More importantly, this hope may extend to humans in the future and possibly cure type 1 diabetes altogether. With 29 million Americans suffering from some form of diabetes and one in four of them unaware of their ailment, we may be in store for a major breakthrough.

The study, published in The Journal of Immunology in late 2015, tested a multitude of compounds in an attempt to find one that could suppress type 1 diabetes while retaining patients’ ability to continue living. The latter part is important to note, since other compounds like dioxin have been found to suppress type 1 diabetes while accumulating within the body and becoming increasingly toxic.

As written in the study, and you may want to skip this part, “We recently discovered 10-chloro-7H-benzimidazo[2,1-a]benzo[de]iso-quinolin-7-one (10-Cl-BBQ), a nanomolar affinity AhR ligand with immunosuppressive activity and favorable pharmacologic properties.”

Yes, the whole paper is like that. But, in short, they found the aptly named BBQ compound is able to bind to T cells and alter their expression in lab mice.

T cells are your body’s militia, which both destroy and retain memory of pathogens, so the afflicted body can better protect against repeat infections. In binding to T cells, BBQ is able to prevent them from developing into pancreas terrorists that prey on insulin-producing cells and cause inflammation.

Researchers remain confident that BBQ not only may lead to serious breakthroughs in the diabetes world, but the entire universe of autoimmune disease. But before we get too excited, BBQ has yet to be clinically tested on humans, and so has a ways to go before hitting pharmacy shelves. If you  would like to help, please refer any diabetic mice you know to the OSU Department of Environmental and Molecular Toxicology.

By Anthony Vitale

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